Dysregulation of Hydrogen Sulfide (H2S) Producing Enzyme Cystathionine -lyase (CSE) Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia Running title: Wang et al.; Low hydrogen sulfide in preeclampsia
نویسندگان
چکیده
Vascular Medicine Unit, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, England; Gustav Born Centre for Vascular Biology, BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; Dept of Maternal-Fetal Medicine, Hospital Clinic-IDIBAPS, University of Barcelona, Spain; Lakehead University, Thunder Bay, Ontario, Canada; Dept of Obstetrics, Gynecology and Reproductive Science, Yale School of Medicine, Yale University, New Haven, CT
منابع مشابه
Effect of Thyrotoxicosis on Gene Expression of Hydrogen Sulfide-producing Enzymes in Epididymal Adipose Tissue of Male Rats
Introduction: Thyroid hormones are involved in the regulation of hydrogen sulfide (H2S) biosynthesis. The aim of this study is to determine effects of thyrotoxicosis on H2S levels and mRNA expression of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) in the adipose tissue of rat. Materials and Methods: Male rats were divided into the ...
متن کاملVASCULAR BIOLOGY, ATHEROSCLEROSIS, AND ENDOTHELIUM BIOLOGY Reduced Cystathionine g-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies Hydrogen Sulfide as a Placental Vasodilator
opyright a 2013 American Society for Inve ublished by Elsevier Inc. All rights reserved ttp://dx.doi.org/10.1016/j.ajpath.2013.01.001 Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in the fetoplacental vasculature. H2S is produced endog...
متن کاملMucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa
Objective(s): This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in rats. Materials and Methods:Thirty-two rats were randomly assigned into 4 groups (8 in each), including: the control group, HCl (10 mM) treated g...
متن کاملProtective Effects of Hydrogen Sulfide in the Ageing Kidney
Aims. The study aimed to examine whether hydrogen sulfide (H2S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H2S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H2S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased ...
متن کاملA cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway
Traditionally, hydrogen sulfide (H2S) was simply considered as a toxic and foul smelling gas, but recently H2S been brought into the spot light of cardiovascular research and development. Since the 1990s, H2S has been mounting evidence of physiological properties such as immune modification, vascular relaxation, attenuation of oxidative stress, inflammatory mitigation, and angiogenesis. H2S has...
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